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fluoro n  (MedChemExpress)


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    MedChemExpress fluoro n
    Fluoro N, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 10 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/fluoro n/product/MedChemExpress
    Average 93 stars, based on 10 article reviews
    fluoro n - by Bioz Stars, 2026-02
    93/100 stars

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    Butyrate reduces type 1, type 2, and type 17 cytokine levels in ex vivo ‐cultured mucosa media from healthy controls and inflammatory bowel disease patients. The effect of butyrate (2 m m ) or dexamethasone treatment (100 n m ) for 24 h on cytokine secretion: TNF (A), IL‐6 (B), IL‐17A (C), IFN‐γ (D), IL‐2 (E), and IL‐10 (F) was evaluated in cultured biopsies from healthy controls (HC, n = 10), non‐inflamed (NI), and inflamed (I) biopsies from patients with inflammatory bowel disease (IBD), including Crohn's disease (CD, n = 9), and ulcerative colitis (UC, n = 9). Cytokine analysis was performed on the culture medium after 24 h using a cytometric bead array (CBA). Statistical analysis: Mann–Whitney test (A–D, F) and unpaired t ‐test (E) (black: between HC and IBD); Wilcoxon matched‐pairs signed‐rank test (A–D, F) and paired t ‐test (E) (green: comparing NI and I tissue in patients with IBD; blue: between control and butyrate or dexamethasone treatment). * P < 0.05; ** P < 0.01.

    Journal: The Febs Journal

    Article Title: Butyrate suppresses mucosal inflammation in inflammatory bowel disease primarily through HDAC3 inhibition in monocytes and macrophages

    doi: 10.1111/febs.70289

    Figure Lengend Snippet: Butyrate reduces type 1, type 2, and type 17 cytokine levels in ex vivo ‐cultured mucosa media from healthy controls and inflammatory bowel disease patients. The effect of butyrate (2 m m ) or dexamethasone treatment (100 n m ) for 24 h on cytokine secretion: TNF (A), IL‐6 (B), IL‐17A (C), IFN‐γ (D), IL‐2 (E), and IL‐10 (F) was evaluated in cultured biopsies from healthy controls (HC, n = 10), non‐inflamed (NI), and inflamed (I) biopsies from patients with inflammatory bowel disease (IBD), including Crohn's disease (CD, n = 9), and ulcerative colitis (UC, n = 9). Cytokine analysis was performed on the culture medium after 24 h using a cytometric bead array (CBA). Statistical analysis: Mann–Whitney test (A–D, F) and unpaired t ‐test (E) (black: between HC and IBD); Wilcoxon matched‐pairs signed‐rank test (A–D, F) and paired t ‐test (E) (green: comparing NI and I tissue in patients with IBD; blue: between control and butyrate or dexamethasone treatment). * P < 0.05; ** P < 0.01.

    Article Snippet: For butyrate effect experiments, 2 m m sodium butyrate (Sigma‐Aldrich, Saint Louis, MO, USA) was added to the culture medium, while 100 n m dexamethasone (Steraloids, Inc., Newport, RI, USA) was used as a positive control, as previously described in ex vivo models [ , ].

    Techniques: Ex Vivo, Cell Culture, MANN-WHITNEY, Control